Clinical Severity in CADASIL Related to Ultrastructural Damage in White Matter
نویسندگان
چکیده
منابع مشابه
Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI.
BACKGROUND AND PURPOSE CADASIL is a newly recognized cause of subcortical ischemic strokes that progressively leads to dementia associated with pseudobulbar palsy and severe motor disability. This deleterious progression and the severity of clinical presentation are widely variable among affected subjects. The exact role played by MRI white-matter abnormalities, a hallmark of the disease, in th...
متن کاملDamage within a network of white matter regions underlies executive dysfunction in CADASIL.
OBJECTIVE To identify the important sites of white matter disruption that underpin executive dysfunction in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), a genetic model of pure subcortical vascular disease. METHODS The anatomic pattern of correlation between tissue integrity and executive function was explored with diffusion tensor imag...
متن کاملDepression in small-vessel disease relates to white matter ultrastructural damage, not disability
OBJECTIVE To determine whether cerebral small-vessel disease (SVD) is a specific risk factor for depression, whether any association is mediated via white matter damage, and to study the role of depressive symptoms and disability on quality of life (QoL) in this patient group. METHODS Using path analyses in cross-sectional data, we modeled the relationships among depression, disability, and Q...
متن کاملExcitotoxic damage to white matter.
Glutamate kills neurons by excitotoxicity, which is caused by sustained activation of glutamate receptors. In recent years, it has been shown that glutamate can also be toxic to white matter oligodendrocytes and to myelin by this mechanism. In particular, glutamate receptor-mediated injury to these cells can be triggered by activation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid,...
متن کاملCerebral hemodynamics and white matter hyperintensities in CADASIL.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small-vessel disease caused by mutations in the NOTCH3 gene on chromosome 19. On magnetic resonance imaging (MRI), subcortical white matter hyperintensities and lacunar infarcts are visualized. It is unknown whether a decrease in cerebral blood flow or cerebrovascular reactivity ...
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ژورنال
عنوان ژورنال: Stroke
سال: 1999
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.30.12.2637